USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P02671 USC-OGP 2-DE database:  P02671 P02671 General information about the entry View entry in simple text format Entry name FIBA_HUMAN Primary accession number P02671 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Fibrinogen alpha chain; Contains: RecName: Full=Fibrinopeptide A; Contains: RecName: Full=Fibrinogen alpha chain; Flags: Precursor;. Gene name Name=FGA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0314: pI=6.63; Mw=68262 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0866: pI=6.55; Mw=64276 SPOT OGP-0867: pI=6.69; Mw=64276 SPOT OGP-0868: pI=6.90; Mw=64276 SPOT OGP-0869: pI=6.98; Mw=64276 SPOT OGP-0870: pI=7.08; Mw=64276 SPOT OGP-0871: pI=6.85; Mw=63930 SPOT OGP-0872: pI=7.19; Mw=63930 SPOT OGP-0873: pI=7.36; Mw=63930 SPOT OGP-0874: pI=7.40; Mw=63758 SPOT OGP-0896: pI=7.13; Mw=52647 SPOT OGP-0902: pI=7.63; Mw=52223 SPOT OGP-0904: pI=7.91; Mw=52223 Cross-references UniProtKB/Swiss-Prot P02671; FIBA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name FIBA_HUMAN Primary accession number P02671 Secondary accession number(s) A8K3E4 D3DP14 D3DP15 Q4QQH7 Q9BX62 Q9UCH2 Sequence was last modified on  October 1, 1996 (version 2) Annotations were last modified on  March 15, 2017 (version 216) Name and origin of the protein Description RecName: Full=Fibrinogen alpha chain; Contains: RecName: Full=Fibrinopeptide A; Contains: RecName: Full=Fibrinogen alpha chain; Flags: Precursor; Gene name Name=FGA Encoded on Name=FGA Keywords 3D-structure; Adaptive immunity; Alternative splicing; Amyloid; Amyloidosis; Blood coagulation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Hydroxylation; Immunity; Innate immunity; Isopeptide bond; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M64982; AAA17056.1; -; Genomic_DNA EMBL M64982; AAA17055.1; -; Genomic_DNA EMBL M58569; AAC97142.1; -; Transcribed_RNA EMBL M58569; AAC97143.1; -; Transcribed_RNA EMBL AF361104; AAK31372.1; -; Genomic_DNA EMBL AF361104; AAK31373.1; -; Genomic_DNA EMBL AK290559; BAF83248.1; -; mRNA EMBL CH471056; EAX04925.1; -; Genomic_DNA EMBL CH471056; EAX04926.1; -; Genomic_DNA EMBL CH471056; EAX04927.1; -; Genomic_DNA EMBL CH471056; EAX04928.1; -; Genomic_DNA EMBL BC098280; AAH98280.1; -; mRNA EMBL BC099706; AAH99706.1; -; mRNA EMBL BC099720; AAH99720.1; -; mRNA EMBL BC101935; AAI01936.1; -; mRNA EMBL J00128; AAA52427.1; -; mRNA EMBL J00127; AAA52426.1; -; mRNA EMBL K02272; AAA52428.1; -; mRNA EMBL M26878; AAA52444.1; -; mRNA CCDS CCDS3787.1; -. [P02671-1]; . CCDS CCDS47152.1; -. [P02671-2]; . PIR A93956; FGHUA; . PIR D44234; D44234; . RefSeq NP_000499.1; NM_000508.4. [P02671-1]; . RefSeq NP_068657.1; NM_021871.3. [P02671-2]; . UniGene Hs.351593; -; . UniGene Hs.612036; -; . PDB 1BBR; X-ray; 2.30 A; F/G/I=26-35 PDB 1DM4; X-ray; 2.50 A; C=26-35 PDB 1FPH; X-ray; 2.50 A; F=26-35 PDB 1FZA; X-ray; 2.90 A; A/D=130-216 PDB 1FZB; X-ray; 2.90 A; A/D=130-216 PDB 1FZC; X-ray; 2.30 A; A/D=130-216 PDB 1FZD; X-ray; 2.10 A; A/B/C/D/E/F/G/H=666-866 PDB 1FZE; X-ray; 3.00 A; A/D=130-216 PDB 1FZF; X-ray; 2.70 A; A/D=130-216 PDB 1FZG; X-ray; 2.50 A; A/D=130-216 PDB 1LT9; X-ray; 2.80 A; A/D=145-210 PDB 1LTJ; X-ray; 2.80 A; A/D=145-210 PDB 1N86; X-ray; 3.20 A; A/D=130-216 PDB 1N8E; X-ray; 4.50 A; A/D=130-218 PDB 1RE3; X-ray; 2.45 A; A/D=145-210 PDB 1RE4; X-ray; 2.70 A; A/D=145-210 PDB 1RF0; X-ray; 2.81 A; A/D=145-210 PDB 1RF1; X-ray; 2.53 A; A/D=145-210 PDB 1YCP; X-ray; 2.50 A; F/N=20-42 PDB 2A45; X-ray; 3.65 A; G/J=36-92 PDB 2FFD; X-ray; 2.89 A; A/D=145-210 PDB 2H43; X-ray; 2.70 A; A/D=130-216 PDB 2HLO; X-ray; 2.60 A; A/D=130-216 PDB 2HOD; X-ray; 2.90 A; A/D/G/J=130-216 PDB 2HPC; X-ray; 2.90 A; A/D/G/J=130-216 PDB 2OYH; X-ray; 2.40 A; A/D=145-210 PDB 2OYI; X-ray; 2.70 A; A/D=145-210 PDB 2Q9I; X-ray; 2.80 A; A/D=130-216 PDB 2XNX; X-ray; 3.30 A; A/D/G/J=130-216 PDB 2XNY; X-ray; 7.50 A; A/D=130-216 PDB 2Z4E; X-ray; 2.70 A; A/D=130-216 PDB 3AT0; X-ray; 2.50 A; B=332-347 PDB 3BVH; X-ray; 2.60 A; A/D=148-209 PDB 3E1I; X-ray; 2.30 A; A/D=130-216 PDB 3GHG; X-ray; 2.90 A; A/D/G/J=20-581 PDB 3H32; X-ray; 3.60 A; A/D=20-216 PDB 3HUS; X-ray; 3.04 A; A/D=145-210 PDB 4F27; X-ray; 1.92 A; Q=336-347 PDB 5CFA; X-ray; 1.45 A; C/D=580-594 PDBsum 1BBR; -; . PDBsum 1DM4; -; . PDBsum 1FPH; -; . PDBsum 1FZA; -; . PDBsum 1FZB; -; . PDBsum 1FZC; -; . PDBsum 1FZD; -; . PDBsum 1FZE; -; . PDBsum 1FZF; -; . PDBsum 1FZG; -; . PDBsum 1LT9; -; . PDBsum 1LTJ; -; . PDBsum 1N86; -; . PDBsum 1N8E; -; . PDBsum 1RE3; -; . PDBsum 1RE4; -; . PDBsum 1RF0; -; . PDBsum 1RF1; -; . PDBsum 1YCP; -; . PDBsum 2A45; -; . PDBsum 2FFD; -; . PDBsum 2H43; -; . PDBsum 2HLO; -; . PDBsum 2HOD; -; . PDBsum 2HPC; -; . PDBsum 2OYH; -; . PDBsum 2OYI; -; . PDBsum 2Q9I; -; . PDBsum 2XNX; -; . PDBsum 2XNY; -; . PDBsum 2Z4E; -; . PDBsum 3AT0; -; . PDBsum 3BVH; -; . PDBsum 3E1I; -; . PDBsum 3GHG; -; . PDBsum 3H32; -; . PDBsum 3HUS; -; . PDBsum 4F27; -; . PDBsum 5CFA; -; . ProteinModelPortal P02671; -; . SMR P02671; -; . BioGrid 108534; 27; . DIP DIP-29643N; -; . IntAct P02671; 18; . MINT MINT-1033042; -; . STRING 9606.ENSP00000306361; -; . ChEMBL CHEMBL2364709; -; . DrugBank DB04919; Alfimeprase; . DrugBank DB00009; Alteplase; . DrugBank DB05099; Ancrod; . DrugBank DB00029; Anistreplase; . DrugBank DB05675; EP-2104R; . DrugBank DB00015; Reteplase; . DrugBank DB00364; Sucralfate; . DrugBank DB00031; Tenecteplase; . iPTMnet P02671; -; . PhosphoSitePlus P02671; -; . SwissPalm P02671; -; . UniCarbKB P02671; -; . BioMuta FGA; -; . DMDM 1706799; -; . OGP P02671; -; . SWISS-2DPAGE P02671; -; . MaxQB P02671; -; . PaxDb P02671; -; . PeptideAtlas P02671; -; . PRIDE P02671; -; . DNASU 2243; -; . Ensembl ENST00000302053; ENSP00000306361; ENSG00000171560. [P02671-1]; . Ensembl ENST00000403106; ENSP00000385981; ENSG00000171560. [P02671-2]; . GeneID 2243; -; . KEGG hsa:2243; -; . UCSC uc003iod.2; human. [P02671-1]; . CTD 2243; -; . DisGeNET 2243; -; . GeneCards FGA; -; . HGNC HGNC:3661; FGA; . HPA CAB016776; -; . HPA HPA051370; -; . HPA HPA064755; -; . MalaCards FGA; -; . MIM 105200; phenotype; . MIM 134820; gene+phenotype; . MIM 202400; phenotype; . MIM 616004; phenotype; . neXtProt NX_P02671; -; . OpenTargets ENSG00000171560; -; . Orphanet 98880; Familial afibrinogenemia; . Orphanet 98881; Familial dysfibrinogenemia; . Orphanet 248408; Familial hypodysfibrinogenemia; . Orphanet 101041; Familial hypofibrinogenemia; . Orphanet 93562; Familial renal amyloidosis due to fibrinogen A alpha-chain variant; . PharmGKB PA429; -; . eggNOG KOG2579; Eukaryota; . eggNOG ENOG410ZYS4; LUCA; . GeneTree ENSGT00830000128240; -; . HOGENOM HOG000285947; -; . HOVERGEN HBG005668; -; . InParanoid P02671; -; . KO K03903; -; . OMA PGSTGTW; -; . OrthoDB EOG091G03M1; -; . PhylomeDB P02671; -; . TreeFam TF351984; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-140875; Common Pathway of Fibrin Clot Formation; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5686938; Regulation of TLR by endogenous ligand; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-977225; Amyloid fiber formation; . SIGNOR P02671; -; . ChiTaRS FGA; human; . EvolutionaryTrace P02671; -; . GeneWiki Fibrinogen_alpha_chain; -; . GenomeRNAi 2243; -; . PMAP-CutDB P02671; -; . PRO PR:P02671; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000171560; -; . CleanEx HS_FGA; -; . ExpressionAtlas P02671; baseline and differential; . Genevisible P02671; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0005938; C:cell cortex; IEA:Ensembl; . GO GO:0009986; C:cell surface; IDA:BHF-UCL; . GO GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:1903561; C:extracellular vesicle; IDA:UniProtKB; . GO GO:0005577; C:fibrinogen complex; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0031091; C:platelet alpha granule; IDA:BHF-UCL; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0005198; F:structural molecule activity; IDA:BHF-UCL; . GO GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0072377; P:blood coagulation; common pathway; IMP:BHF-UCL GO GO:0072378; P:blood coagulation; fibrin clot formation; IDA:UniProtKB GO GO:0007160; P:cell-matrix adhesion; IDA:BHF-UCL; . GO GO:0043623; P:cellular protein complex assembly; IDA:BHF-UCL; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0042730; P:fibrinolysis; IDA:UniProtKB; . GO GO:0043152; P:induction of bacterial agglutination; IDA:CACAO; . GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:2000261; P:negative regulation of blood coagulation; common pathway; TAS:BHF-UCL GO GO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:BHF-UCL; . GO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL; . GO GO:0031639; P:plasminogen activation; IDA:UniProtKB; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; . GO GO:0045921; P:positive regulation of exocytosis; IDA:BHF-UCL; . GO GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL; . GO GO:0090277; P:positive regulation of peptide hormone secretion; IDA:BHF-UCL; . GO GO:0050714; P:positive regulation of protein secretion; IDA:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; NAS:BHF-UCL; . GO GO:0045907; P:positive regulation of vasoconstriction; IDA:BHF-UCL; . GO GO:0006461; P:protein complex assembly; IMP:UniProtKB; . GO GO:0051258; P:protein polymerization; IDA:BHF-UCL; . GO GO:0051592; P:response to calcium ion; IDA:BHF-UCL; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . CDD cd00087; FReD; 1; . Gene3D 3.90.215.10; -; 1; . Gene3D 4.10.530.10; -; 1; . InterPro IPR014716; Fibrinogen_a/b/g_C_1; . InterPro IPR014715; Fibrinogen_a/b/g_C_2; . InterPro IPR002181; Fibrinogen_a/b/g_C_dom; . InterPro IPR012290; Fibrinogen_a/b/g_coil_dom; . InterPro IPR021996; Fibrinogen_aC; . InterPro IPR020837; Fibrinogen_CS; . Pfam PF08702; Fib_alpha; 1; . Pfam PF12160; Fibrinogen_aC; 1; . Pfam PF00147; Fibrinogen_C; 1; . SMART SM00186; FBG; 1; . SMART SM01212; Fib_alpha; 1; . SUPFAM SSF56496; SSF56496; 1; . PROSITE PS00514; FIBRINOGEN_C_1; 1; . PROSITE PS51406; FIBRINOGEN_C_2; 1; .

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